本文通过150例正常新生儿,36例轻度窒息新生儿及3例严重窒息并发肾功能衰竭新生儿之各种尿酶检测,发现轻度窒息者尿酶增加(Lys 3.6倍,LDH 1.2倍,NAG 1.7倍),严重窒息并发肾功能衰竭者各种尿酶可增加数十倍,且LDH V亦显著增加(P值均<0.001)。作者认为尿酶及其同功酶的检测可作为诊断肾小管功能损伤的方法。并认为凡有围产期窒息的新生儿,常规查尿酶,可作为监测肾功能方法之一,利于即时采取措施,减低死亡率. In this paper, 150 cases of normal newborns, 36 cases of mild asphyxia neonates and 3 cases of severe asphyxia newborns with renal failure were detected by various urinary enzymes and found that mild asphyxia increased urinary enzymes (Lys 3.6 times, LDH 1.2 times, NAG 1.7 times), various urease in patients with severe asphyxia complicated with renal failure can increase tens of times, and LDH V also increased significantly (P <0.001). Authors believe that the detection of urine enzymes and isozymes can be used as a diagnostic method of renal tubular damage. And that all newborns with perinatal asphyxia suffocation, urease routine examination, as one of the ways to monitor renal function, which will help to take immediate measures to reduce mortality.