目的 :探讨原发性肝癌 ( PHC)的危险因素。方法 :对杭州市 10 0例 PHC进行 1∶ 1配对病例对照研究 ,通过条件 L ogistic回归多因素和单因素分析筛选主要危险因素。结果 :结果显示乙型肝炎史与 PHC发生最为密切( OR=18.2 6、95 % CI为 4.40～ 75 .77)。另外 ,肿瘤家族史 ( OR=2 .75 )、心理因素 ( OR=2 .5 1)、胆囊炎 ( OR=5 .0 0 )为 PHC危险因素。结论 :PHC与乙型肝炎史、肿瘤家族史、胆囊炎史和心理因素有关 Objective: To investigate the risk factors for primary liver cancer (PHC). METHODS: A 1:1 matched case-control study was performed on 100 PHC patients in Hangzhou. Major risk factors were screened by conditional L ogistic regression multifactorial and univariate analysis. Results: The results showed that the history of hepatitis B was most closely related to PHC (OR = 18.2, 95% CI 4.40 ~ 75.77). In addition, family history of cancer (OR=2.75), psychological factors (OR=2.51), and cholecystitis (OR=5.0) were risk factors for PHC. Conclusion : PHC is related to the history of hepatitis B, family history of cancer, history of cholecystitis and psychological factors