论文部分内容阅读
鉴于中医药复杂巨系统求解过程在数学上的不可描述性,借鉴国内外先进的计算机化学与粉体材料科学理念与方法,以由水溶性和脂溶性两类物质组成的复方丹参制剂处方为模型药物,采集有效部位物料体系的物理化学特征参数(有关化学成分的熵、焓、表面能、电性等)、相关复合工艺特征参数(操作温度、搅拌速度、包覆时间等)及目的产物复合粒子性能特征参数(微结构参数与生物药剂学性能)等数据,建立中药复合粒子设计与制备工艺小型数据库,应用中药学、计算机化学、物理化学等跨学科交叉研究“中药粒子复合技术”的规律,探索中药复合粒子制备工艺微/纳米尺度有序组合机制,尝试以现代物理化学手段调控中药多元组分微结构及性能。为中药复方体系实现“表征参数检测—工艺过程参数筛选—目的产物性能优化”提供一种全新的研究模式。
In view of the mathematical unsolvable nature of the solution process of complex giant system in traditional Chinese medicine, we draw on the advanced scientific concepts and methods of computer chemistry and powder materials science in China and abroad and take the prescription of compound Salvia miltiorrhiza compound which is composed of water-soluble and fat-soluble substances as the model (Including the entropy, enthalpy, surface energy, electrical property, etc.) of the material system of the effective part of the drug, the relevant complex process parameters (operating temperature, stirring speed, coating time and the like) Particle performance parameters (microstructure parameters and biopharmaceutical performance) and other data, the establishment of traditional Chinese medicine composite particle design and preparation of small databases, the application of traditional Chinese medicine, computer chemistry, physical chemistry and other interdisciplinary research “Chinese medicine particle composite technology” To explore the micro / nano-scale ordered assembly mechanism of traditional Chinese medicine composite particle preparation process, try to use modern physical and chemical means to regulate the microstructure and properties of multi-component Chinese medicine. It provides a brand new research mode for the realization of TCM compound system, “Characterization parameter detection - Process parameter screening - Optimization of target product performance”.