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本文134例强直性脊椎炎(Ankylosing Spondylitis,即AS)HLA—B27全部为阳性。男性108例,女性26例,男:女为4.15:1。RF除1例为阳性外,其余全部为阴性。5例家系遗传图有利地证明了AS具有遗传倾向,其中有明显的家族遗传史者117例,占87.31％。AS早期常被误诊为类风湿性关节灸(RA)等,对5岁以后发病的男性关节炎,结合家族史,应当考虑AS的可能性。并应常规进行HLA—B27、骶髂关节X线片、血沉、抗“O”、抗核抗体(ANA)、免疫球蛋白及C—反应蛋白(CRP)等检查。针对性进行家系研究,有利于AS的早期发现,并对早期病人提出预防措施及治疗原则。
In this paper, 134 cases of ankylosing spondylitis (AS) HLA-B27 are all positive. 108 males, 26 females, males: 4.15: 1 females. RF except 1 case was positive, the rest were all negative. 5 cases of familial inheritance map proves that AS has a genetic predisposition, including 117 cases of obvious family history, accounting for 87.31%. AS early often misdiagnosed as rheumatoid arthritis (RA), etc., after the age of 5 onset of male arthritis, combined with family history, the possibility of AS should be considered. And routine HLA-B27, sacroiliac joint X-ray, ESR, anti-O, anti-nuclear antibody (ANA), immunoglobulin and C-reactive protein (CRP) and other tests. Targeted pedigree research is conducive to the early detection of AS, and proposing preventive measures and treatment principles for early patients.