已知苯巴比妥具有诱导肝微粒体酶系活性的作用,导致HDL 胆固醇血浆浓度升高。但苯巴比妥是否升高胆固醇、甘油三酯和HDL亚组分的浓度还不清楚。本文作者对长期应用苯巴比妥的住院病人进行了研究。21名年龄在20～65岁的男性癫痫患者作为实验组,患者至少已应用苯巴比妥(95～300 mg/d)5年;22名年龄在23～67岁的男性精神病患者 It is known that phenobarbital has the effect of inducing liver microsomal enzyme activity resulting in an increase in the concentration of HDL cholesterol plasma. Whether or not phenobarbital increases cholesterol, triglyceride, and HDL sub-components is unclear. The authors studied long-term use of phenobarbital inpatients. Twenty-one male patients with epilepsy aged 20-65 years were enrolled in the study. Patients were treated with phenobarbital (95-300 mg / d) for at least 5 years. Twenty-two male psychiatric patients aged 23-67 years