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A study on the physiological-biochemical changes of different ramie(Boehmeria Jacq. ) varieties under drought stress was carried out, the results showed that relative water contents(RWC) decreased and RPP increased with the increase of drought stress. Compared with drought sensitive varieties, drought resistant varieties had higher RWC in leaves but lower RPP. Peroxidase activity of drought-resistance varieties changed from low to high whereas sensitive ones changed in opposite direction. Proline contents of drought sensitive varieties was higher than those of drought resistant ones under a certain degree drought stress. Proline accumulation in drought resistant varieties was faster than that in drought sensitive ones under serious drought stress.MDA contents in leaf was increased under drought stress. MDA contents increased slowly in resistant varieties while that increased rapidly in sensitive ones.