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目的 研究血管紧张素Ⅱ受体拮抗剂罗沙坦对高血压肾小动脉重建的逆转作用。方法 16wk龄 大鼠分为 :正常血压大鼠 (WKY)组、自发性高血压大鼠 (SHR)对照组、罗沙坦治疗高剂量组 (15mg·kg-1·d-1)和罗沙坦治疗低剂量组 (0 75mg·kg-1·d-1)。每组 6只大鼠 ,饲养 10wk。在肾组织切片上用光镜结合计算机图像分析法观测肾内小动脉的几何形态学指标 ,离体肾脏灌流法测定最小肾血管阻力。结果 罗沙坦高剂量组的尾动脉收缩压、肾内小动脉壁厚、壁面积、壁厚内径比和最小肾血管阻力 ,均较高血压对照组显著下降或减小 ;罗沙坦低剂量组的肾内小动脉壁厚和壁厚内径比较高血压对照组显著下降或减小。结论 AngⅡ受体拮抗剂能逆转SHR肾小动脉的重建 ,而且是非血压依赖性的
Objective To investigate the reversal effect of losartan, an angiotensin Ⅱ receptor antagonist, on the remodeling of hypertensive renal arterioles. Methods Wistar rats were randomly divided into three groups: normal Wistar rats (WKY), spontaneous hypertensive rats (SHR), losartan high dose (15 mg · kg -1 · d -1) Tan treatment of low-dose group (0 75mg · kg-1 · d-1). Six rats in each group were housed for 10 weeks. Morphological parameters of renal arterioles were observed by light microscopy and computer image analysis on the sections of renal tissue. The renal renal perfusion method was used to determine the minimal renal vascular resistance. Results Compared with the high blood pressure control group, the systolic blood pressure of the caudal artery, the wall thickness, the area of the renal arterioles, the ratio of the wall thickness and the minimum renal vascular resistance in the high-dose rosuvastatin group were significantly decreased or decreased; Group of renal artery wall thickness and wall thickness than the control group were significantly lower or lower blood pressure. Conclusions AngⅡ receptor antagonists can reverse the remodeling of SHR renal arterioles and are non-pressure dependent