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目的探讨甘露糖结合凝集素相关的丝氨酸蛋白酶(MASP-2)在甲状腺肿瘤组织中的表达及其临床意义。方法应用免疫组化SP技术检测26例甲状腺乳头状癌(PTC)及其癌旁正常甲状腺组织,30例甲状腺腺瘤组织(TA)中MBL蛋白的表达含量;结合甲状腺乳头状癌患者的临床病理参数进行分析。结果 MASP-2在甲状腺乳头状癌、腺瘤中的表达分别为(0.332±0.046)和(0.221±0.030),癌旁正常甲状腺组织中无表达,各组间差异有统计学意义(P<0.01);与性别、年龄、分期、肿瘤大小、淋巴结转移无明显相关性(P>0.05)。结论 MASP-2在甲状腺肿瘤的发生过程中起了一定作用。
Objective To investigate the expression of mannose-binding lectin-associated serine protease (MASP-2) in thyroid tumors and its clinical significance. Methods Immunohistochemical SP technique was used to detect the expression of MBL protein in 26 cases of thyroid papillary carcinoma (PTC) and adjacent normal thyroid tissue and 30 cases of thyroid adenoma (TA). Combined with the clinicopathological features of thyroid papillary carcinoma Parameters for analysis. Results The expressions of MASP-2 in papillary thyroid carcinoma and adenoma were (0.332 ± 0.046) and (0.221 ± 0.030), respectively, but there was no expression in normal thyroid tissue adjacent to the tumor. The difference was statistically significant (P <0.01) ). There was no significant correlation with gender, age, stage, tumor size and lymph node metastasis (P> 0.05). Conclusions MASP-2 plays a role in the development of thyroid tumors.