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目的研究ΔNP63/TAP63在上皮性卵巢肿瘤组织中的表达及其与临床病理特征的关系。方法运用荧光定量聚合酶链反应方法检测2002年-2004年54例卵巢上皮性肿瘤中ΔNP63/TAP63的基因水平。结果 33例卵巢上皮细胞癌组织中ΔNP63的表达高于21例良性上皮性肿瘤中组织。卵巢上皮细胞癌中的表达强度与肿瘤组织病理学分期相关(P<0.05),良性肿瘤的表达低于恶性肿瘤(P<0.05)。ΔNP63的表达高于TAP63(P<0.05);各组间TAP63的表达差异无统计学意义(P>0.05)。结论ΔNP63在上皮性卵巢癌中高表达,可能成为上皮性卵巢癌诊断及预后的分子标志物。
Objective To study the expression of ΔNP63 / TAP63 in epithelial ovarian tumor and its relationship with clinicopathological features. Methods The mRNA level of ΔNP63 / TAP63 was detected in 54 cases of ovarian epithelial tumors from 2002 to 2004 by fluorescence quantitative polymerase chain reaction. Results The expression of ΔNP63 in 33 cases of epithelial ovarian cancer tissues was higher than that in 21 cases of benign epithelial tumors. The expression of ovarian epithelial cell carcinoma correlated with tumor histopathological staging (P <0.05), benign tumor was lower than that of malignant tumor (P <0.05). The expression of ΔNP63 was higher than that of TAP63 (P <0.05). There was no significant difference in the expression of TAP63 between groups (P> 0.05). Conclusion ΔNP63 is highly expressed in epithelial ovarian cancer and may be a molecular marker for the diagnosis and prognosis of epithelial ovarian cancer.