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目的 探讨电化学疗法对中晚期胰体尾癌的治疗效果及其安全性。 方法 1989年 5月至 1996年 6月应用电化学疗法治疗中晚期胰体尾癌 18例 (A组 ) ;1996年 7月至 1999年 9月治疗16例 (B组 ) ,除术中应用电化学治疗外 ,术后经腹腔化疗泵注射化疗 (5 氟尿嘧啶 5 0 0mg,甲酰四氢叶酸钙 30 0mg以及卡铂 2 0 0mg,每周 1次 )。 结果 (1)两组患者肿瘤大小都有不同程度缩小或消失 ;(2 )两组患者均有较好的止痛效果 ;(3)腹水控制 :A组无效 ,B组部分有效 (6 6 7% ) ;(4 )两组患者均无手术死亡及严重并发症。 结论 电化学疗法对于中晚期胰体尾癌是一种安全有效的治疗手段 ,可以减轻痛苦 ,改善生活质量。同时辅以化疗泵注射治疗对控制腹水有一定效果
Objective To investigate the curative effect and safety of electrochemotherapy on advanced pancreatic body and tail cancer. Methods From May 1989 to June 1996, 18 patients (group A) with advanced pancreatic body end-cancer were treated with electrochemotherapy. From July 1996 to September 1999, 16 patients (group B) were treated. Chemotherapy, postoperative intraperitoneal chemotherapy pump injection chemotherapy (5 fluorouracil 500mg, 30000 leucovorin and carboplatin 200mg, once a week). Results: (1) The size of tumor in both groups decreased or disappeared in varying degrees; (2) Both groups had better analgesic effect; (3) Ascites control was not effective in group A and partly in group B (66.7% ); (4) There was no operative death and serious complications in both groups. Conclusion Electrochemotherapy is a safe and effective treatment for advanced pancreatic body and tail cancer, which can relieve the pain and improve the quality of life. At the same time, supplemented by chemotherapy pump injection therapy to control ascites have a certain effect