细胞的骨架结构主要由三种原纤维组成,即微管、微丝和中间丝。近年来,通过对构成中间丝的蛋白质的生化及免疫学分析表明,中间丝蛋白具有细胞类别特异性的特点。检测不同细胞内的中间丝蛋白类型,有助于了解该细胞的来源。根据此特点,人们将中间丝分型应用于肿瘤诊断取得了可喜的进展。本文就中间丝分型及其在肿瘤诊断中的应用作一简要的综 The skeletal structure of the cell consists mainly of three fibrils, namely microtubules, microfilaments, and intermediate filaments. In recent years, biochemical and immunological analysis of the proteins that make up the intermediate filaments have shown that intermediate filament proteins have cell-type specificity. Detecting the type of intermediate filament protein in different cells helps to understand the source of the cell. Based on this feature, people have made gratifying progress in the application of intermediate filaments for tumor diagnosis. This article gives a brief summary of the classification of intermediate filaments and their applications in tumor diagnosis.