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目的研究不同放射性浓度(188)~Re-DTPA-脱氧葡萄糖(DG)对人 MCF-7乳腺癌细胞凋亡的影响及其作用机制。方法用流式细胞仪检测(188)~Re-DTPA-DG 处理后 MCF-7乳腺癌细胞的凋亡。将人 MCF-7乳腺癌细胞分成3组:(188)~Re-DTPA-DG 实验组、(188)~ReO_4~-对照组和生理盐水组。其中前2组分3个不同放射性浓度组:37、55.5、74 kBq/ml。结果 (188)~Re-DTPA-DG、(188)~ReO_4~-均能导致肿瘤细胞发生凋亡,实验组与(188)~ReO_4~-对照组及生理盐水组在不同放射性浓度下差异均有显著性(P<0.01),随着放射性浓度增加,凋亡程度增大;(188)~Re-DTPA-DG 较(188)~ReO_4~-更易诱导凋亡发生。结论(188)~Re-DTPA-DG 能导致肿瘤细胞凋亡,并且与放射性浓度相关;其机制可能是辐射导致 DNA 严重损伤,使细胞周期发生阻滞。
Objective To study the effect of different concentrations of radioactive (188) Re-DTPA-deoxyglucose (DG) on the apoptosis of human breast cancer cell line MCF-7 and its mechanism. Methods The apoptosis of MCF-7 breast cancer cells treated with (188) ~ Re-DTPA-DG was detected by flow cytometry. Human MCF-7 breast cancer cells were divided into three groups: (188) ~ Re-DTPA-DG experimental group, (188) ~ ReO 4 ~ -control group and saline group. Among them, the first two components of three different radioactive concentrations: 37,55.5,74 kBq / ml. Results (188) ~ Re-DTPA-DG and (188) ~ ReO 4 ~ -were all able to induce apoptosis in tumor cells. The difference of the radioactive concentrations between the experimental group and the 188 control group and the ReO 4 ~ (188) ~ Re-DTPA-DG was more likely to induce apoptosis than (188) ~ ReO 4 ~ (-). Conclusions (188) ~ Re-DTPA-DG can induce tumor cell apoptosis and is related to radioactive concentration. The mechanism may be that DNA damage is caused by radiation and the cell cycle arrest occurs.