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目的:探索强化、达标血脂控制对2型糖尿病发病影响。方法:2型糖尿病患者144名,按3:1的比例随机分成强化组和对照组。强化组接受强化血脂控制。对照组在门诊治疗。为期4年的随访,终点事件为第一次发生视网膜病变的时间。结果:强化组血脂控制优于对照组(P<0.05)。强化组19人(18.7%),对照组7人(21.7%)发生视网膜病变(P=0.679)。总胆固醇≤4.66 mmol/l(风险比(HR),1.546;95%置信区间(CI)0.449-5.320;P=0.489),低密度脂蛋白胆固醇≤2.59 mmol/l(HR,0.704;95%CI0.215-2.307;P=0.562),及甘油三酯≤1.7 mmol/l(HR,1.004;95%CI0.398-2.530;P=0.993)与糖尿病视网膜病变发生无显著关联性。结论:强化达标控制血脂不能降低糖尿病视网膜病变发生风险。
Objective: To explore the effects of intensive and standard lipid control on type 2 diabetes. Methods: 144 patients with type 2 diabetes were randomly divided into intensive group and control group according to the ratio of 3: 1. Intensive group received intensive lipid control. Control group in outpatient treatment. A four-year follow-up, the end point of the first retinopathy time. Results: The blood lipid control in the intensive group was better than that in the control group (P <0.05). 19 (18.7%) in the intensive group and 7 (21.7%) in the control group had retinopathy (P = 0.679). Total cholesterol ≤4.66 mmol / l (hazard ratio (HR), 1.546; 95% CI 0.449-5.320; P = 0.489), low density lipoprotein cholesterol ≤2.59 mmol / l (HR, 0.704; 95% CI0 .215-2.307; P = 0.562), and triglycerides ≤1.7 mmol / l (HR, 1.004; 95% CI0.398-2.530; P = 0.993) were not associated with diabetic retinopathy. CONCLUSIONS: Strengthening the compliance of blood lipids can not reduce the risk of diabetic retinopathy.