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造血生长因子(HGF)是一种糖蛋白激素,具有促进造血祖细胞增殖、分化和调节成熟血细胞机能的作用.作用于从多能祖细胞至循环成熟细胞分化瀑布的不同阶段,包括促红细胞生成素(Ep)、粒-巨噬细胞集落刺激因子(GM-CSF)、粒集落刺激因子(G-CSF)、巨噬细胞集落刺激因子(M-CSF)和白细胞介素3(lL-3)等.最近多种HGF已纯化、克隆化,通过重组DNA技术已大量生产,并于临床试用.生物学特性Ep由肾小管周围细胞和肝细胞产生,血浆平均浓度25mU/ml.T淋巴细胞、单核细胞或巨噬细胞、内皮细胞、纤维母细胞是HGF的重要细胞来源.纤维母细胞和内皮细胞不断合成M-CSF,血浆生理活性为174±76U/ml.G-CSF约见于10%的正常人血
Hematopoietic growth factor (HGF) is a glycoprotein hormone that promotes the proliferation, differentiation and regulation of hematopoietic progenitor cells in mature blood cells.It acts on different stages of differentiation from multipotent progenitor cells to circulating mature cells, including erythropoiesis (Ep), GM-CSF, G-CSF, M-CSF and IL-3, Etc. A variety of HGFs have recently been purified and cloned and have been mass-produced by recombinant DNA technology and are being clinically tested. Biological characteristics Ep is produced by peritubular tubular cells and hepatocytes at an average plasma concentration of 25 mU / ml T lymphocytes, Monocytes or macrophages, endothelial cells, and fibroblasts are important cellular sources of HGF Fibroblasts and endothelial cells continue to synthesize M-CSF with a plasma physiological activity of 174 ± 76 U / ml.G-CSF is found in 10% Normal human blood