结直肠癌半数以上的患者就诊时已属晚期患者,除手术治疗外,均要接受全身性化疗。奥沙利铂(oxalip latin L-OHP)与5-Fu联合组成的FOLFOX方案已成为结直肠癌标准的化疗方案,其疗效已得到肯定,但很多患者在使用中很快出现耐药,甚至有些患者化疗前就已耐药。目前普遍认为核苷酸切除 More than half of patients with colorectal cancer have been treated late patients, in addition to surgical treatment, have to undergo systemic chemotherapy. The FOLFOX regimen of oxaliplatin L-OHP and 5-Fu has become the standard chemotherapy regimen for colorectal cancer and its efficacy has been validated, but many patients are rapidly becoming resistant to some of these drugs and even some Patients have been resistant before chemotherapy. Nucleotide excision is generally considered