作者首次报道1例慢性复发性轴索神经病(CRAN)。女性,50岁。诉进行性肢体、躯干、面部感觉障碍3年,肢体乏力2年,同时体重逐断下降10公斤。曾因左侧坐骨神经病行椎板切除术,因子 宫纤维瘤行子宫全切术。无服药、神经中毒、滥用酒精史。其姐20岁时急性瘫痪发作,现残留患肢麻木。神经系统检查示轻度双侧面瘫和味觉障碍,手内侧肌轻度废用性萎缩,上肢肌力4～5级,拇趾背屈、髋部屈肌减弱,四肢主观痛觉障碍,但客观轻触觉,温度觉正常。除左拇趾外,振动觉、关节位置觉正常,共济运动正常。实验室检查:全血细胞计数、血沉、肝肾功能、血清蛋白电泳、肌酸激酶、风湿因子、甲状腺毒素、VitB_(12)、叶酸浓度、尿卟吩胆素原 The authors first reported a case of chronic recurrent axonal neuropathy (CRAN). Female, 50 years old. V. Progressive limbs, torso, facial sensory disturbances 3 years, limb weakness 2 years, while body weight decreased by 10 kg. Had left sciatic nerve disease laminectomy, hysterectomy due to uterine fibroids. No medication, nervous poisoning, abuse of alcohol history. His sister 20 years old when acute paralysis, numbness is residual limbs. Neurological examination showed mild bilateral facial paralysis and dysgeusia, mild disuse atrophy of the medial hand muscles, upper extremity muscle strength of 4 to 5, dorsal hallux flexion, weakening of the hip flexor, subjective pain disorders in the extremities, but objectively mild Tactile, normal temperature. In addition to the left thumb toe, vibration, joint position normal, common movement together. Laboratory tests: whole blood count, ESR, liver and kidney function, serum protein electrophoresis, creatine kinase, rheumatoid factor, thyrotoxin, VitB 12, folic acid concentration,