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血管紧张素Ⅱ受体(ANGⅡR)和降钙素基因相关肽受体(CGRPR)同属于G蛋白藕联受体家族。研究发现。单独激活ANGⅡR或CGRPR和同时激活两受体对细胞的命运表现出不同甚至相反的作用。目前已知,CGRP受体是由降钙素受体样受体(CRLR)、受体活性修饰蛋白-1(RAMP1)、受体组分蛋白(RCP)3个组分组成。ANGⅡR和CGRPR间的相互作用可能发生在细胞膜的信号转导、细胞浆信号通路以及核内的基因转录等水平。本文综述了ANGⅡR和CGRPR在跨膜信号蛋白(如G蛋白及caveolae/caveoilins)、胞浆-胞核内信号蛋白(如NADPH氧化酶、MAPK家族)水平的相互作用,可望从心血管受体间信号整合改变的新视角来解释心血管疾病的发病机制。
Angiotensin II receptor (ANGⅡR) and calcitonin gene-related peptide receptor (CGRPR) belong to the family of G protein-coupled receptors. The study found. Activation of ANG IIR or CGRPR alone and simultaneous activation of both receptors show different or even opposite effects on cell fate. It is known that the CGRP receptor is composed of three components of calcitonin receptor-like receptor (CRLR), receptor activity modifying protein-1 (RAMP1) and receptor component protein (RCP). ANGⅡR and CGRPR interactions may occur in the cell membrane signal transduction, cytoplasmic signaling pathway and the nuclear gene transcription level. This review summarizes the interaction between ANG IIR and CGRPR at the level of transmembrane signaling proteins such as G-protein and caveolae / caveoilins and cytosolic-cytoplasmic signaling proteins (eg, NADPH oxidase, MAPK family) A new perspective of the signal integration changes between the interpretation of the pathogenesis of cardiovascular disease.