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本文选择Ⅰ、Ⅱ期原发性高血压(EH)患者共69例(合并冠心病者13例)。测定血脂质过氧化物(LPO)的主要降解产物——丙二醛(MDA)。同时测定红细胞膜超氧化物歧化酶(SOD)及血内源性类洋地黄物质(EDLS)。发现EH患者血MDA、EDF均高于正常对照组(P<0.001)。SOD低于对照组(P<0.001)。本文在国内外首次发现MDA与EDF呈正相关。提示LPO可能作为一种继发机制参与高血压的病理过程。
This article chooses Ⅰ, Ⅱ patients with essential hypertension (EH) a total of 69 cases (13 cases of coronary heart disease). Malondialdehyde (MDA), the major degradation product of lipid peroxidation (LPO), was measured. At the same time, erythrocyte membrane superoxide dismutase (SOD) and blood-derived digitalis-like substance (EDLS) were determined. The blood levels of MDA and EDF in patients with EH were significantly higher than those in controls (P <0.001). SOD was lower than the control group (P <0.001). This paper for the first time at home and abroad found a positive correlation between MDA and EDF. It is suggested that LPO may participate in the pathological process of hypertension as a secondary mechanism.