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恶性肿瘤的发生、发展与机体的免疫状况有直接的因果关系,本文报导对93例胃癌患者进行细胞免疫功能和血清免疫球蛋白水平的测定:治疗前患者的淋巴细胞转化率明显低于正常对照组,随着病变的发展,病期越晚,细胞免疫功能降低越严重。IgM水平明显降低,IgG、IgA水平无明显变动。手术切除对免疫功能有一定暂时性抑制作用,对术前免疫降低组手术切除后一周复查即可提高,免疫治疗对免疫功能虽有不同程度提高,但无显著差异。术前术后定期检测淋巴细胞转化率对判断近期预后和早期复发有一定帮助。
There is a direct causal relationship between the occurrence and development of malignant tumors and the immune status of the body. This article reports the determination of cellular immune function and serum immunoglobulin levels in 93 patients with gastric cancer: the lymphocyte transformation rate before treatment is significantly lower than that of normal controls. The group, with the development of lesions, the later the disease period, the more severe the reduction of cellular immune function. IgM levels were significantly reduced, and there was no significant change in IgG and IgA levels. Surgical resection has a certain temporary inhibition of immune function. The preoperative reduction of immunosuppression group can be improved after one week of resection. Although immunotherapy has different degrees of improvement in immune function, there is no significant difference. Preoperative and postoperative examinations of lymphocyte transformation rate are helpful to determine the short-term prognosis and early recurrence.