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研究了将聚乙二醇用作相转移催化剂及其对亲核取代反应的改善．先将雌二醇经溴化制得２或４溴雌二醇，再分别在氯仿中以聚乙二醇（ＰＥＧ４００）作相转移催化剂（ＰＴＣ）进行亲核取代反应制备２或４甲氧基雌二醇．发现其适宜条件为：反应温度６０～６５℃，搅拌反应时间１．５ｈ，试剂比例底物为甲醇ＫＯＨＰＥＧ＝１２０８００．８，获得较高亲核取代产率：２甲氧基雌二醇６６．７％及４甲氧基雌二醇７０．３％，结果良好，操作简便．
The use of polyethylene glycol as a phase transfer catalyst and its improvement of the nucleophilic substitution reaction were studied. First estradiol obtained by bromination 2 or 4 bromo-estradiol, and then in chloroform to polyethylene glycol (PEG 400) for phase transfer catalyst (PTC) nucleophilic substitution reaction preparation 2 Or 4 methoxy oestradiol. The optimum conditions were as follows: the reaction temperature was 60-65 ℃, the reaction time was 1.5h, and the ratio of reagents was methanol KOHPEG = 120800.8, yielding higher nucleophilic substitution yield: 2-methoxyestradiol 66 .7% and 4-methoxyestradiol 70.3%, the results are good, easy to operate.