论文部分内容阅读
目的探讨血清中介素(IMD)在脓毒症发生发展中的作用。方法选择2015年8月1日-11月30日宁夏医科大学总医院重症医学科收治的71例感染患者,按患者感染的严重程度分为全身炎症反应综合征(SIRS)组16例、脓毒症组20例、严重脓毒症组17例及脓毒性休克组18例;选择同期17例健康体检者作为对照组。所有研究对象于入院24 h内取静脉血检测血清IMD水平,并进行急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、序贯器官衰竭估计(SOFA)评分、检测降钙素原(PCT)值、乳酸(Lac)水平及记录患者28 d的预后。结果四组患者血清IMD水平均低于对照组(P<0.001),随着脓毒症病情加重,血清IMD水平逐渐降低(P<0.008);存活组血清IMD水平高于死亡组(P<0.05)。Spearman相关性分析结果显示:血清IMD与PCT、Lac水平、APACHEⅡ和SOFA评分均呈负相关(P均<0.001)。结论 IMD参与了脓毒症的发生发展过程,并与病情严重程度及预后密切相关。
Objective To investigate the role of serum interleukin (IMD) in the development of sepsis. Methods Seventy-one infected patients admitted to the Department of Critical Care Medicine, General Hospital of Ningxia Medical University from August 1, 2015 to November 30, 2015 were divided into 16 patients with systemic inflammatory response syndrome (SIRS) according to the severity of their infection, sepsis 20 cases of disease group, 17 cases of severe sepsis group and 18 cases of septic shock group; 17 healthy subjects were selected as the control group. All the subjects were given intravenous blood serum levels of IMD within 24 h after admission, and APACHE II and SOFA scores of acute physiology and chronic health assessment (APACHE II) and procalcitonin (PCT) Lactic acid (Lac) levels and prognosis of patients on the 28th day. Results Serum IMD levels in all four groups were significantly lower than those in control group (P <0.001). Serum IMD level decreased gradually with the severity of sepsis (P <0.008) ). Spearman correlation analysis showed that serum IMD was negatively correlated with PCT, Lac levels, APACHE II and SOFA scores (all P <0.001). Conclusion IMD is involved in the development of sepsis and is closely related to the severity and prognosis.