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目的探讨血管内皮细胞生长因子(VEGF)和微血管密度(MVD)与大肠癌肝转移的关系。方法收集88例大肠癌患者的临床病理资料,检测VEGF血浆浓度、肿瘤组织含量,进行免疫组织化学染色,并计数微血管密度。结果血浆VEGF浓度与肝转移及TNM分期显著相关,肿瘤组织含量与肿瘤浸润深度、淋巴结转移、肝转移及TNM分期显著相关,VEGF染色阳性率与肝转移显著相关。VEGF和MVD正相关。术后肝转移患者的血浆VEGF浓度、肿瘤组织含量和染色阳性率以及MVD均显著高于无肝转移病例。结论VEGF和MVD与大肠癌的进展相关,是术后肝转移的预测指标。
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and microvessel density (MVD) and hepatic metastasis in colorectal cancer. Methods The clinical and pathological data of 88 patients with colorectal cancer were collected. The plasma concentrations of VEGF and the contents of tumor tissue were detected. Immunohistochemical staining and microvessel density were counted. Results The plasma concentration of VEGF was significantly correlated with liver metastasis and TNM stage. The tumor content was significantly correlated with the depth of tumor invasion, lymph node metastasis, liver metastasis and TNM staging. The positive rate of VEGF staining was significantly correlated with liver metastasis. Positive correlation between VEGF and MVD. Plasma VEGF concentration, tumor content, positive staining rate and MVD in patients with postoperative liver metastasis were significantly higher than those without liver metastasis. Conclusions VEGF and MVD are correlated with the progression of colorectal cancer and are the predictors of postoperative liver metastasis.