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目的观察胸腔内交替注射顺铂(PDD)、白细胞介素-2(IL-2)序贯全身应用NP方案治疗非小细胞肺癌合并恶性胸腔积液的短期疗效。方法将我院收治的恶性胸腔积液患者32例均行B超定位,将中心静脉导管一端置入胸腔内,另一端接一次性负压引流袋,缓慢引流,待胸水消失或很少量时,经导管每次向胸腔内交替注入顺铂(DDP)40～60mg、白细胞介素-2(IL-2)400～600万U,重复应用2～3次,序贯应用盖诺40mg第1、8天、顺铂(DDP)40～60mg第2、3、4天,全身化疗,观察局部用药后胸水变化及全身化疗后肺内肿块变化。结果胸水治疗有效率为90,6%,肺内肿块有效率为37,5%。结论顺铂、白细胞介素-2交替胸腔内注入、联合NP方案化疗治疗肺癌合并恶性胸腔积液可以提高疗效并且对身体损伤较小。
Objective To observe the short-term curative effect of intra-thoracic injection of cisplatin (PDD) and interleukin-2 (IL-2) sequential systemic NP regimen in the treatment of non-small cell lung cancer with malignant pleural effusion. Methods 32 patients with malignant pleural effusion admitted to our hospital underwent B-positioning. One end of the central venous catheter was placed in the thoracic cavity, and the other end was connected with a disposable negative pressure drainage bag, which was slowly drained until the pleural effusion disappeared or a small amount , 40-60 mg of cisplatin (DDP) and 4-6 million U of interleukin-2 (IL-2) were alternately infused through the catheter into the thoracic cavity. The application was repeated for 2 to 3 times. , 8 days, 40-60 mg of cisplatin (DDP) for 2, 3 and 4 days, systemic chemotherapy, changes of pleural effusion after local administration and changes of lung mass after systemic chemotherapy. Results pleural effusion treatment efficiency was 90,6%, lung mass effective rate was 37,5%. Conclusions Alternate intrapleural injection of cisplatin and interleukin-2 combined with NP regimen in the treatment of lung cancer complicated with malignant pleural effusion may improve the curative effect and cause less damage to the body.