人体细胞的正常生长有赖于细胞周期中各种调节因子的平衡调控,任何一种调控因子发生紊乱将导致细胞异常增殖,从而诱发肿瘤[1]。p16基因是1994年Kamb和Nobori同时发现的新型抑癌基因,位于人类第9号染色体短臂上(9p21),编码由148个氨基酸组成,相对分子质量为16 000。p16蛋白与周 The normal growth of human cells depends on the balance regulation of various regulatory factors in the cell cycle, and the disorder of any regulatory factors will lead to abnormal proliferation of cells, thereby inducing tumors [1]. The p16 gene is a novel tumor suppressor gene discovered by Kamb and Nobori in 1994. It is located on the short arm of human chromosome 9 (9p21) and is encoded by 148 amino acids with a relative molecular weight of 16 000. P16 protein and week