胃肠癌发病率居我国恶性肿瘤之首 ,对于诊断时已为晚期或术后复发病人常选择化疗。氟尿嘧啶 (5 ＦＵ)是化疗中的主要药物之一 ,同时合用醛氢叶酸钙 (ＣＦ)可增加疗效已得到公认。为了选择最佳的给药剂量及方法 ,ｄｅＧｒａｍｏｎ等[1 ,2 ]采用大剂量ＣＦ加 5 ＦＵ持续滴注 48 The incidence of gastrointestinal cancer ranks first among malignant tumors in our country, and chemotherapy is often chosen for patients who have been diagnosed with advanced or postoperative recurrence. Fluorouracil (5 FU) is one of the main drugs for chemotherapy, and it has been recognized that the combined use of calcium hypofluorite (CF) can increase the efficacy. In order to select the best dose and method of administration, deGramon et al [1,2] used high-dose CF plus 5 FU continuous infusion 48