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目的通过meta分析探讨地塞米松对急性高原病的预防作用,为部队官兵预防急性高原病提供一定的依据。方法计算机检索关于地塞米松和急性高原病的文献,筛选出6篇随机对照研究进行meta分析,地塞米松组的总人数为121人,安慰剂组的总人数为119人,RR值及其95%CI用于评估地塞米松对急性高原病(acute mountain sickness,AMS)的预防作用。结果地塞米松明显降低了AMS的发病率(RR=0.69)。结论部队官兵进入高原之前可以预防性服用地塞米松,减少AMS的发生。
Objective To explore the preventive effect of dexamethasone on acute altitude sickness by meta-analysis, and provide some evidences for military officers and soldiers in preventing acute altitude sickness. METHODS: A computer-based search of literature on dexamethasone and acute mountain sickness was conducted. Six randomized controlled trials were selected for meta-analysis. The total number of dexamethasone groups was 121 and that of the placebo group was 119. The RR values 95% CI was used to evaluate the preventive effect of dexamethasone on acute mountain sickness (AMS). Results Dexamethasone significantly reduced the incidence of AMS (RR = 0.69). Conclusion The officers and men of the armed forces can take dexamethasone prophylactically before entering the plateaus to reduce the occurrence of AMS.