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目的:观察罗格列酮与二甲双胍对多囊卵巢胰岛素抵抗治疗的效果。方法:选择2004-01/2007-12于我院不孕门诊就诊的多囊卵巢综合征伴胰岛素抵抗的患者为研究对象,两组分别服用罗格列酮及二甲双胍3个月,再服克罗米芬,1组仅用克罗米芬,测定所有患者治疗后的排卵率、妊娠率。结果:罗格列酮与二甲双胍均能改善卵巢的排卵功能提高妊娠率,罗格列酮与二甲双胍对排卵与妊娠率的提高无统计学差异。结论:二甲双胍安全有效无潜在致畸作用且价格便宜适合首先选用。
Objective: To observe the effect of rosiglitazone and metformin on the treatment of polycystic ovary insulin resistance. Methods: Patients with polycystic ovary syndrome and insulin resistance who were treated in infertility clinics of our hospital from January 2004 to December 2007 were selected as study subjects. Two groups were treated with rosiglitazone and metformin for 3 months respectively before taking clomiphene citrate , A group of only clomiphene, measured after treatment in all patients the ovulation rate, pregnancy rate. Results: Both rosiglitazone and metformin could improve the ovulation function and pregnancy rate. Rosiglitazone and metformin had no significant difference on ovulation and pregnancy rate. CONCLUSIONS: Metformin is safe and effective without potential teratogenicity and is inexpensive for first choice.