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目的观察急性心肌梗塞(AMI)后血中心肌肌钙蛋白Ⅰ(cTnⅠ)的动态变化。方法应用免疫干膜层析技术,连续测定了40例AMI早期(1～8h)入院患者和10例正常人血中cTnⅠ,结果与心肌酶(CK、CKMB)对比。结果AMI时血中cTnⅠ升高时间较早,持续时间更长,且对心肌细胞损伤诊断的准确性、灵敏性和特异性均优于心肌酶,尤其cTnⅠ定性测定方法简单,出结果迅速。结论心肌肌钙蛋白Ⅰ定性测定对急性心肌梗塞的诊断具有重要的临床价值
Objective To observe the dynamic changes of cardiac troponin Ⅰ (cTn Ⅰ) after acute myocardial infarction (AMI). Methods The levels of cTnⅠ in 40 AMI patients (1 ~ 8h) admitted to hospital and 10 normal controls were measured by immunofluorescence technique. The results were compared with those of CK and CK. Results In the AMI, the elevated cTnI in blood was earlier and longer, and the accuracy, sensitivity and specificity of the diagnosis of myocardial cell injury were better than that of myocardial enzymes. In particular, the qualitative determination of cTnI was simple and the result was rapid. Conclusion The qualitative determination of cardiac troponin I has important clinical value in the diagnosis of acute myocardial infarction