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对４４例原发于皮肤粘膜的恶性黑色累瘤（恶黑）进行光镜观察及ＨＭＢ４５，Ｓ—１００蛋白，Ｖｉｍｅｎｔｉｍ免疫组化研究。光镜见恶黑瘤细胞形态及细胞排列方式多种多样，易与各种低分化癌、肉瘤、淋巴瘤相混淆。ＨＭＢ４５、Ｓ—１００蛋白、Ｖｉｍｅｎｔｉｎ免疫组化检测，其阳性率分别为８８．６％，９５．５％。幻。７％。结果提示，ＨＭＢ４５对恶黑具有较高的特异性和敏感性，对恶黑的诊断有重要意义。Ｓ—１００蛋白，Ｖｉｍｅｎｔｉｎ对恶黑有较高的敏感性，两者配合使用，对恶黑的诊断有辅助作用。
Forty-four cases of malignant black tumors (bad black) that were originally in the skin and mucous membranes were observed by light microscopy and HMB45, S-100 protein, and Vimentim immunohistochemical studies. The light microscope shows that the malignant melanoma cell morphology and cell arrangement are various and easy to be confused with various poorly differentiated carcinomas, sarcomas, and lymphomas. The positive rates of HMB45, S-100 protein and Vimentin immunohistochemistry were 88.6% and 95.5%, respectively. fantasy. 7%. The results suggest that HMB45 has a high specificity and sensitivity to erythema and it is of great significance for the diagnosis of thiabain. S-100 protein, Vimentin has a higher sensitivity to black, the two used in conjunction with the diagnosis of evil black can help.