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在HCV感染宿主过程中,病毒必须首先结合到靶细胞表面,经受体的介导进入细胞,然后才能复制,引起相关的病理变化;因此如何终止丙型肝炎的慢性化进展,特别是阻断HCV的感染过程是关键的问题[1]。阻断HCV感染首先涉及到宿主细胞表面的HCV受体或辅助受体,相关的研究刚开始。现在初步研究结果证实:丙型肝炎病毒的包膜蛋白E1和E2可能是和靶细胞结合的配体,导致病毒进入宿主细胞。由于HCV基因的变异主要反映在病毒包膜E2蛋白,所以E2蛋白的高变区（HVR）决定了
During HCV infection of the host, the virus must first bind to the target cell surface, be mediated by the receptor into the cell, and then replicate, causing the associated pathological changes; thus how to stop the chronic hepatitis C progression, especially the block The process of HCV infection is a key issue [1]. Blocking HCV infection first involves the HCV receptor or co-receptor on the host cell surface, and related research has just begun. Now preliminary results confirm that the envelope proteins E1 and E2 of Hepatitis C virus may be ligands that bind to the target cells, resulting in the entry of the virus into the host cells. Since the variation of the HCV gene is mainly reflected in the viral envelope E2 protein, the hypervariable region (HVR) of the E2 protein determines