论文部分内容阅读
目的分析乳腺癌术后骨转移的临床特征。方法对407例原发乳腺癌术后发生骨转移的情况进行回顾性分析。结果 50例患者术后发生骨转移。这50例患者中,术后30个月内发生骨转移的病例占54.0%,5年内骨转移发生率为76.0%,发病年龄≤50岁的占60%。病理类型以浸润性导管癌为主的占82.0%。骨转移部位最多发生在脊柱,以胸椎、腰椎为主。其次是骨盆、肋骨、胸骨、颅骨、下肢骨。乳腺癌术后是否出现骨转移在年龄、腋淋巴结转移、孕激素受体(PR)、癌基因CerbB2表达方面无统计学差异(P>0.05)。但在肿瘤病理类型及雌激素受体(ER)表达方面的差异有统计学意义(P<0.05)。结论乳腺癌术后30个月内为骨转移高发期,骨转移部位以脊柱及骨盆、肋骨、胸骨多见。乳腺癌术后发生骨转移与年龄、腋淋巴结转移、PR、CerbB2表达方面无关,与肿瘤病理类型、ER有关。
Objective To analyze the clinical features of postoperative bone metastasis of breast cancer. Methods A retrospective analysis of 407 cases of primary breast cancer after bone metastases occurred. Results Fifty patients developed bone metastases after operation. Among the 50 patients, 54.0% had bone metastases within 30 months after operation, 76.0% had bone metastases within 5 years, and 60% patients had onset ≤50 years of age. Pathological type of invasive ductal cancer accounted for 82.0%. Bone metastases occurred in the spine at the most to the thoracic and lumbar-based. Followed by the pelvis, ribs, sternum, skull, lower extremity bone. There was no significant difference in age, axillary lymph node metastasis, progesterone receptor (PR) and oncogene CerbB2 expression in breast cancer after operation (P> 0.05). However, there was significant difference in tumor pathological types and estrogen receptor (ER) expression (P <0.05). Conclusion Breast cancer is the most frequent bone metastasis within 30 months after operation. The spine and pelvis, ribs and sternum are the most common sites of bone metastases. Bone metastasis of breast cancer has nothing to do with the age, axillary lymph node metastasis, PR, CerbB2 expression, and tumor pathological type, ER related.