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据《中华医学杂志》2000年8月80卷第8期报道 广州中山医科大学第一医院神经科王建、刘焯霖等,为探讨细胞色素P-450酶基因多态性与帕金森病(PD)的关系,选择确诊的PD患者158例和正常人150例,应用聚合酶链反应-限制性片段长度多态性技术和等位基因特异性扩增技术检测CYP1A1及CYP2E1基因多态性,并分析比较早发和晚发PD组与相应对照组间多态性频率的差异。 结果表明:(1)CYP1A1基因MspⅠ多态位
According to the “Chinese Medical Journal” August 2000 80 Volume 8 reported Zhongshan Hospital, Guangzhou Neurology Wang Jian, Liu Zhuo Lin, etc., in order to explore the cytochrome P-450 enzyme gene polymorphism and Parkinson’s disease (PD) 158 patients with PD and 150 normal subjects were selected. The polymorphisms of CYP1A1 and CYP2E1 were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and allele-specific amplification (PCR) The frequency of polymorphism between PD group and corresponding control group was higher in early onset and late onset. The results showed that: (1) CYP1A1 gene Msp Ⅰ polymorphism