镁离子是一种重要的内源性离子和辅酶因子,参与体内诸如氧化磷酸化、糖酵解、基因转录、蛋白质合成等多种重要的生命活动,并在临床医疗实践中应用广泛。近年来,随着人类对镁离子与癫癎之间关系研究的不断深入,发现镁离子可以用于癫癎的预防与治疗,甚至有学者提出可以作为难治性癫癎的辅助治疗药物。本文对近年最新研究进展进行回顾,从细胞外低镁与癫癎的关系、癫癎患者血清镁离子异常、镁的抗癫癎作用及可能机制等几个方面进行综述。 Magnesium ion is an important endogenous ion and coenzyme, which is involved in many important life activities such as oxidative phosphorylation, glycolysis, gene transcription and protein synthesis, and is widely used in clinical practice. In recent years, with the continuous research on the relationship between magnesium ions and epilepsy, we found that magnesium ions can be used in the prevention and treatment of epilepsy. Some scholars even proposed adjuvant therapy for refractory epilepsy. This article reviews the latest research progress in recent years, and reviews the relationship between low extracellular magnesium and epilepsy, serum magnesium abnormality in patients with epilepsy, anti-epileptic effect of magnesium and its possible mechanism.