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目的探讨活性炭血液灌流(HPA)对急性重度敌敌畏中毒的代谢动力学的影响。方法通过静脉推注敌敌畏(100 mg/kg)染毒雄性比格犬,并随机分成治疗对照组(常规治疗)和HPA组(HPA+常规治疗),每组各5只。动态检测两组比格犬血浆中敌敌畏浓度,利用DAS2.1.1软件计算两组毒物代谢动力学参数。结果(1)静脉推注敌敌畏后,敌敌畏在比格犬体内分布与清除符合二室开放模型,Vd=(17.803±10.345)L/kg,t1/2=(6.260±3.078)h,清除率(C l)=(1.955±0.757)L/(h.kg);两组间毒物代谢动力学参数差异无统计学意义(P>0.05)。(2)HPA治疗期间,HPA组比治疗对照组的体内存留时间(MRT)、t1/2缩短,C l增大,两组间差异有统计学意义(P<0.05)。结论在急性重度敌敌畏中毒的早期应用HPA技术可短时间内降低血浆中毒物浓度,改变毒物代谢动力学参数,但对体内毒物负荷总量的清除作用尚不明显。
Objective To investigate the effect of activated carbon hemoperfusion (HPA) on the metabolism of acute severe dichlorvos poisoning. Methods Male Beagle dogs were injected intravenously with dichlorvos (100 mg / kg) and randomly divided into treatment group (n = 5) and HPA group (n = 5). The concentrations of dichlorvos in plasma of two Beagle dogs were detected dynamically. The toxicokinetic parameters of two groups were calculated by DAS2.1.1 software. Results (1) After intravenous injection of dichlorvos, the distribution and clearance of dichlorvos in beagle dogs were in accordance with the two-compartment open model, with Vd = (17.803 ± 10.345) L / kg and t1 / 2 = (6.260 ± 3.078) C l) = (1.955 ± 0.757) L / (h.kg); There was no significant difference in toxicokinetic parameters between the two groups (P> 0.05). (2) During HPA treatment, the in vivo retention time (MRT), t1 / 2 and C l of HPA group were significantly shorter than those of the control group (P <0.05). Conclusion In the early application of acute severe dichlorvos poisoning HPA technology can reduce plasma concentrations of poison in a short time, changing the toxicokinetic parameters, but the removal of the total amount of toxicant in vivo is not yet obvious.