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目的探讨乙肝免疫球蛋白(HBIG)预防乙型肝炎病毒(HBV)母婴传播的效果。方法选取2010年2月—2015年1月于珠海市平沙医院进行产前检查的200例HBV阳性产妇,采用随机抽签法分为观察组和对照组,每组100例。对照组新生儿出生后使用HBIG,观察组产妇及新生儿均使用HBIG,比较两组新生儿出生时、出生7个月后HBs Ag及乙肝表面抗体(抗-HBs)阳性率。结果观察组新生儿出生时、出生后7个月HBs Ag阳性率低于对照组,抗-HBs阳性率高于对照组,差异有统计学意义(P<0.05)。结论 HBV阳性产妇使用HBIG可降低新生儿HBV感染率,提高新生儿获得抗-HBs效果。
Objective To investigate the effect of hepatitis B immunoglobulin (HBIG) on the prevention of hepatitis B virus (HBV) maternal-to-infant transmission. Methods From February 2010 to January 2015, 200 cases of HBV-positive mothers who had prenatal examination in Pingsha Hospital of Zhuhai City were selected and randomized into observation group and control group with 100 cases in each group. In the control group, HBIG was used after birth, HBIG was used in both mothers and newborns in the observation group, and the positive rates of HBs Ag and HBsAg (anti-HBs) after birth were compared between the two groups at birth. Results At birth, the positive rate of HBs Ag in the observation group was lower than that in the control group at 7 months after birth, and the positive rate of anti-HBs was higher than that in the control group. The difference was statistically significant (P <0.05). Conclusions The use of HBIG in HBV-positive mothers can reduce the HBV infection rate in newborns and improve the anti-HBs effect in neonates.