论文部分内容阅读
微囊藻毒素(microcystins,MCs)是藻类水华暴发时出现频率最高,毒性作用最强的藻毒素之一。除急性毒性作用以外,大量动物实验和流行病学调查表明,长期、低剂量摄入MCs最大的健康危害是提高癌症的发生率,尤其是肝癌的发生。对于MCs诱发癌变已经进行了大量的研究,尤其是对其作用机制的研究已引起了广泛的兴趣。本文分别从MCs引起的信号网络、细胞周期调控、氧化胁迫、基因表达、免疫系统监控等内在的变化,以及MCs与环境中其他致癌物质的协同作用等外界因素方面,对MCs诱发癌症的作用机制作一综述。
Microcystins (MCs) are one of the most toxic and toxic algal toxins that occur in algal blooms. In addition to acute toxic effects, a large number of animal experiments and epidemiological surveys show that long-term, low-dose intake of MCs, the greatest health hazard is to increase the incidence of cancer, especially the occurrence of liver cancer. A great deal of research has been done on the MCs induced carcinogenesis, especially the research on its mechanism of action has aroused widespread interest. In this paper, MCs induced by the signal network, cell cycle regulation, oxidative stress, gene expression, immune system monitoring and other intrinsic changes, as well as MCs and other environmental carcinogens synergistic effects and other external factors, the role of MCs-induced cancer Make a review.