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上皮细胞间质转化(EMT)可增强细胞的侵袭、迁移能力,促进多种肿瘤的转移,但无法解释肿瘤原发灶和转移灶上皮的相似性。本研究着力于阐明间质细胞上皮转化(MET)在转移灶形成过程中的重要性,采用膀胱癌TSU-Pr1(T24)细胞株接种联合免疫缺陷小鼠,来观察其接种后是否有转移能力的增?
Epithelial cell mesenchymal transition (EMT) can enhance cell invasion and migration, promote the metastasis of many kinds of tumors, but can not explain the similarity between primary tumor and metastatic epithelium. This study focused on elucidating the importance of interstitial epithelial metaplasia (MET) in the formation of metastases. The bladder cancer TSU-Pr1 (T24) cell line was inoculated with immunodeficient mice to observe whether there was metastasis after inoculation Increase?