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目的:探讨疾病状态下新生儿甲状腺功能参数异常的临床意义。方法:回顾分析107例住院的生后3天以上的足月新生儿,血清游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)的结果,并进行统计学处理。结果:低T3综合征61例(57.01%),低T3和T4综合征30例(28.04%),继发性甲减8例(7.48%),高TSH血症8例(7.48%)。经检验,一般疾病组和危重疾病组的胎龄、血清FT3的差异有统计学意义(P<0.05),而两组FT4、TSH、体重的差异无统计学意义(P>0.05);所有患儿胎龄、体重与血清FT3、FT4、TSH无关(P>0.05)。结论:疾病状态下新生儿甲状腺功能参数的异常,主要以低T3综合征、低T3和低T4综合征的形式表现,尤其是危重疾病状态下FT3水平更低,可作为新生儿危重病情判断的一个参考指标。
Objective: To investigate the clinical significance of neonatal thyroid dysfunction in disease status. Methods: The results of 107 hospitalized neonates with term infants more than 3 days after birth, serum free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were retrospectively analyzed. Statistical analysis. Results: There were 61 cases (57.01%) with low T3 syndrome, 30 (28.04%) with low T3 and T4 syndrome, 8 cases (7.48%) with secondary hypothyroidism, and 8 cases (7.48%) with hypercholesteremia. The results showed that there was significant difference in gestational age and serum FT3 between the general disease group and the critical disease group (P <0.05), while there was no significant difference between the two groups in the FT4, TSH, body weight (P> 0.05) The gestational age, body weight and serum FT3, FT4, TSH (P> 0.05). CONCLUSIONS: Thyroid dysfunction in neonates with disease states is mainly characterized by low T3 syndrome, low T3 and low T4 syndromes, especially in critical disease states, and may be used as a marker of critical illness in newborns A reference index.