消炎痛虽然具有极好的消炎镇痛作用,但须长期用药才能达到最佳疗效,且副反应发生率较高,以胃肠道和CNS反应较常见,前者与消炎痛抑制了胃粘膜前列腺素合成有关;后者与消炎痛的血浆浓度过高有关。因此,改进剂型和合并用药,以增 Although indomethacin has an excellent anti-inflammatory analgesic effect, long-term medication is needed to achieve the best therapeutic effect and the incidence of side effects is high. Gastrointestinal and CNS reactions are more common. The former and indomethacin inhibit gastric mucosal prostaglandin Synthesis; the latter is associated with high plasma concentrations of indomethacin. Therefore, to improve the dosage form and combination of drugs to increase