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以聚(ε-己内酯-b-L-丙交酯)/聚乙二醇单甲醚(P(CL-b-LLA)-b-mPEG)和聚(ε-己内酯-b-D,L-丙交酯)/聚乙二醇单甲醚(P(CL-b-DLLA)-b-mPEG)两种两亲嵌段共聚物为载体,选择了物理状态完全不同、而疏水性相近的吲哚美辛和维生素E为模型药物,研究了药物包载对高分子胶束形态的影响.发现两种药物在高分子胶束内部的增溶均会导致胶束形态发生显著改变,变化行为与胶束内核的结晶性和药物疏水性有关.另外,还研究了两种嵌段共聚物的载药性能,发现非结晶性疏水内核共聚物的药物包载率明显大于可结晶疏水内核的共聚物.
Poly (ε-caprolactone-bL-lactide) / polyethylene glycol monomethyl ether (P (CL-b-LLA) -b-mPEG) and poly (ε-caprolactone- Lactide) / polyethylene glycol monomethylether (P (CL-b-DLLA) -b-mPEG) amphiphilic block copolymer as the carrier, select the physical state is completely different, and similar hydrophobicity of the indole The effects of drug loading on the morphology of polymeric micelles were investigated with the model drug, and the solubilities of the two drugs in micellar micelles resulted in significant changes in micellar morphology, The crystallinity of the micellar core is related to the hydrophobicity of the drugs.In addition, the drug loading properties of the two block copolymers were also investigated, and it was found that the drug loading of the non-crystalline hydrophobic core copolymer was significantly higher than that of the copolymer .