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目的:利用基因芯片技术研究伊犁地区汉、维两个民族乙型肝炎病毒(HBV)耐药基因的差异性。方法:收集2014年1月-2015年12月我院收治的汉族及维吾尔族(以下简称“维族”)慢性HBV感染患者各50例,患者均经基因芯片技术筛选确诊存在天然HBV耐药基因(耐核苷酸类药物),观察HBV耐药基因分型特点及对核苷酸类药物的耐药突变位点的情况。结果:汉族HBV感染患者的耐药基因型集中于B、C型,且以C型为主,而维族以D型为主,两组各基因型比较,差异均有统计学意义(P<0.05)。汉族患者在rt204位点变异明显,而维族在rtn236t、rta181v/t+rtn236t位点变异明显,差异均有统计学意义(P<0.05)。结论:在新疆伊犁地区天然HBV病毒耐药基因患者中,汉族及维族耐药基因分型及耐药基因突变位点均存在显著差异,临床可通过基因芯片技术筛选变异靶点,选择合适的敏感药物。
OBJECTIVE: To study the difference of hepatitis B virus (HBV) resistance genes between Han and Uygur nationality in Yili region by using gene chip technique. Methods: Fifty patients with chronic HBV infection from January 2014 to December 2015 in our hospital were enrolled in this study. All patients were diagnosed with natural HBV resistance by gene chip technique Gene (resistant to nucleotide drugs), observed HBV resistance genotyping characteristics and nucleotide resistance mutations in the situation. Results: The genotypes of HBV resistance in Han patients were mainly B and C genotypes, and genotype C was the predominant, while Uygur genotypes were mainly D genotypes. There was significant difference in genotypes between the two groups (P <0.05 ). Han patients at rt204 significant variation, and Uighurs in rtn236t, rta181v / t + rtn236t significant variation in loci, the difference was statistically significant (P <0.05). CONCLUSION: Among the patients with natural HBV resistance gene in Yili region of Xinjiang, there are significant differences in the genotyping of drug resistance genes and the mutation sites of drug-resistant genes in Han and Uighur people. Clinically, the mutation target can be screened by gene chip technology and the appropriate sensitivity drug.