ｃｍｙｃ是常见的激活癌基因，它有导致细胞的恶性转化作用．ｐ５３基因是重要的抑癌基因，其突变失活在肿瘤的发生过程中起重要作用［１］．我们应用免疫组织化学技术检测了７９例原发性肝细胞癌和６３例癌旁肝细胞中ｃｍｙｃ和Ｐ５３蛋白的分布与表达，对Ｃｍｙｃ... Cmyc is a common activating oncogene that causes malignant transformation of cells. P53 gene is an important tumor suppressor gene, and mutation inactivation plays an important role in the process of tumor [1]. We applied immunohistochemistry to detect the distribution and expression of cmyc and P53 protein in 79 cases of primary hepatocellular carcinoma and 63 cases of paracancerous liver cells.