组织蛋白酶K是溶酶体半胱氨酸蛋白酶中的番木瓜酶超家族成员,它能降解细胞外基质,还包含了独特的溶胶原活性。组织蛋白酶K参与心血管疾病的多个致病过程,与动脉粥样硬化的发生发展密切相关,是血管重塑、腹主动脉瘤生长和破裂过程中的主要胶原酶之一,还可能参与主动脉瓣狭窄的致病过程。 Cathepsin K is a member of the papaya enzyme superfamily of lysosomal cysteine ​​proteases that degrade the extracellular matrix and also contains unique sologen activity. Cathepsin K is involved in a number of pathogenic processes of cardiovascular disease and is closely related to the development of atherosclerosis. It is one of the major collagenases in the process of vascular remodeling and abdominal aortic aneurysm growth and rupture. Aortic stenosis pathogenic process.