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目的 观察强化锌奶粉和不同含锌量的饲料对小鼠造血系统的影响。方法 昆明小鼠３６ 只按体重随机分为４ 组（ 对照组、奶粉组、等量锌组、高锌组） ，分别饲以含强化锌奶粉饲料和不同含锌量的饲料２４ 周。结果 ①高锌组喂养１２ 周后血红蛋白（Ｈｂ） 降低（与对照组相比Ｐ＜０ ．０５） ，１６ 周时进一步下降（ Ｐ＜ ０．０１）。２４ 周时Ｈｂ、ＲＢＣ、ＨＣＴ、ＭＣＶ 均明显下降（ Ｐ＜ ０．０１），中性粒细胞绝对值下降（Ｐ＜０．０５），骨髓幼红细胞增生。血清及肝、肾中锌含量增加但铜含量下降，血清铜蓝蛋白下降。②奶粉组１６ 周时各项指标无明显变化，２４ 周时变化与高锌组相似。２４ 周时等量锌组小鼠肝、肾铜含量轻度降低（Ｐ＜０ ．０５） 。结论 高锌摄入可导致贫血，一般情况下，食用强化锌奶粉是安全的，但长期超量食用可干扰造血系统。
Objective To observe the effects of fortified zinc milk powder and diets containing different amounts of zinc on the hematopoietic system in mice. Methods 36 Kunming mice were randomly divided into 4 groups according to body weight (control group, milk powder group, equivalent zinc group, high zinc group), and fed diets containing fortified zinc milk powder and different zinc contents for 24 weeks respectively. Results ① In the high zinc group, hemoglobin (Hb) was decreased after 12 weeks of feeding (P <0. 05 compared with the control group), and further decreased at 16 weeks (P <0.01). The levels of Hb, RBC, HCT and MCV decreased significantly at 24 weeks (P <0.01), the absolute value of neutrophils decreased (P <0.05), and erythrocytes proliferated. Serum and liver, kidney zinc content increased but the copper content decreased, serum ceruloplasmin decreased. ② milk powder group at 16 weeks no significant changes in all indicators, changes at 24 weeks and high zinc group similar. At the 24th week, the copper content of liver and kidney in the same zinc group was slightly decreased (P <0 .05). Conclusion High intake of zinc can lead to anemia. In general, it is safe to consume fortified zinc milk powder, but long-term over-consumption can interfere with the hematopoietic system.