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众所周知,一部份白血病前期(以下简称白前)患者于数月或数年后转为急性白血病,而另一部份白前患者则不转为白血病。所谓白前患者包括难治性贫血、获得性特发性铁粒幼细胞性贫血、原始细胞过多的难治性贫血及慢性粒-单核细胞白血病。作者为探讨其规律性,对21例白前患者的骨髓以半固体琼脂法进行培养和观察,观察项目为;①有无粒-巨噬细胞集落;②克隆数;③内生性骨髓粒-巨噬细胞的祖细胞增殖和调节因子(colony-stimulating activily,
It is well-known that some patients with pre-leukemia (hereinafter referred to as pre-white) are converted to acute leukemia in a few months or years, while the other part of pre-white patients are not converted to leukemia. The so-called white pre-patients include refractory anemia, acquired idiopathic granulitocytic anemia, refractory anemia with excess pristine cells, and chronic myelomonocytic leukemia. In order to explore its regularity, the bone marrow of 21 cases of pre-white patients were cultured and observed by semi-solid agar method. The items were: (1) with or without granulocyte-macrophage colony; (2) number of colonies; (3) Macrophage progenitor cell proliferation and regulatory factors (colony-stimulating activily,