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目的研究2000-2009年世界各地不同物种流感病毒神经氨酸酶的进化特征和关键位点的变异情况。结论从NCBI数据库下载所需序列,采用生物信息软件对其氨基酸序列进行种系发生树的构建,以及序列特性的分析。结果新型流感病毒和猪/禽流感病毒NA蛋白在进化关系上非常接近,并且抗原决定簇和糖基化位点的变异也大致相同。结论新型毒株NA蛋白可能由早期的H1N1猪/禽流感病毒进化而来,在进化过程中,一些重要位点的变异导致NA蛋白发生抗原性变异,从而导致流感的大爆发。
Objective To study the evolutionary characteristics and variation of key sites of influenza virus neuraminidase from 2000 to 2009 in different regions of the world. Conclusion The desired sequence was downloaded from NCBI database. The phylogenetic tree of its amino acid sequence was constructed with bioinformatics software and the sequence characteristics were analyzed. Results The novel influenza virus and the swine / bird flu virus NA protein are evolutionarily closely related, and the variation of epitopes and glycosylation sites is also approximately the same. Conclusion The new strain of NA protein may be evolved from the early H1N1 swine / bird flu virus. Some important sites in the evolution process lead to antigenic variation of NA protein, leading to a large outbreak of influenza.