线粒体是人体细胞重要的细胞器之一,主要功能是合成ATP,为细胞生命活动提供直接能量。线粒体解偶联剂使氧化磷酸化解偶联,是线粒体内的关键调节剂。简要综述线粒体解偶联剂和以解偶联作用为靶标的药物发现方面的研究进展。 Mitochondria are one of the most important cellular organelles in human cells. Their main function is to synthesize ATP, which provides direct energy for the life activities of cells. Mitochondrial uncoupler oxidative phosphorylation uncoupling, is a key regulator of mitochondria. The progress of research on mitochondrial uncoupler and drug discovery with uncoupling effect are briefly reviewed.