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123例儿童白血病中Ph~1阳性的有8例(占6.5％)。4例为典型的慢性粒细胞白血病(CGL),4例为急性白血病。4例慢粒患儿中,有2例已发生急性变。这6例急性病例(包括4例急白与2例慢粒急性变)的幼稚细胞根据其形态学与免疫学的特征提示3例为急淋变,1例为粒、淋的混合型,1例为急粒变。这6例中有5例获得缓解,但持续缓解在一年以上的只有2例。这2例中有1例在急性变时其原始细胞Ph~1阴性。另1例最初为急粒变,缓解后急变又变为急淋变。从细胞遗传学的研究,这8例儿童中有2例表现出染色体罕见的移位。对3例急白患儿的骨髓进行连续检查其Ph~1阳性细胞的百分率在获得缓解时低于6％。
123 cases of childhood leukemia Ph ~ 1 positive in 8 cases (6.5%). 4 cases of typical chronic myeloid leukemia (CGL), 4 cases of acute leukemia. In 4 children with CML, 2 had an acute change. These 6 acute cases (including 4 cases of acute and 2 cases of acute acute myelogenous leukemia cells) showed morphological and immunological features of 3 cases of acute lymphoid lesions, 1 case of mixed granules of granuloma and 1 Example for acute grain change. Five of the six patients were relieved, but only two continued to have relief over a year. One of these two cases had a negative Ph ~ 1 in its primary cells during acute change. Another case of acute granulositis initially, acute and acute edema after remission. From the cytogenetic study, two of the eight children showed a rare chromosomal shift. The percentage of Ph ~ 1 positive cells in the bone marrow of 3 children with acute white stria was less than 6% when they were relieved.