论文部分内容阅读
目的探讨Ⅲ度羊水胎粪污染与新生儿脑组织氧饱和度的关系及影响新生儿脑组织氧饱和度的围生因素。方法将2004年1月至2005年3月在暨南大学第二临床学院妇产科分娩的Ⅲ度羊水胎粪污染的足月新生儿,根据胎粪吸入综合征(MAS)诊断标准分为MAS组和无MAS组,羊水清的足月新生儿为对照组,在新生儿出生后2～8h,第2、3、5、7天测量脑组织氧饱和度。结果MAS组新生儿出生后2～8h,第2、3、5、7天脑组织氧饱和度与无MAS组、对照组比较明显降低,差异有极显著性意义(P<0.01),无MAS组新生儿在第2、3天脑组织氧饱和度与对照组比较明显降低,差异有极显著性意义(P<0.01)。顺产组新生儿出生后2～8h脑组织氧饱和度比剖宫产组低,差异有极显著性意义(P<0.01),在第2、3、5、7天比较差异则无显著性意义(P>0.05)。新生儿出生后脑组织氧饱和度持续异常的围生因素有:绒毛膜羊膜炎合并Ⅲ度羊水胎粪污染及Ⅲ度羊水胎粪污染伴随新生儿窒息。结论MAS组新生儿脑组织氧饱和度受到影响并发生脑损伤。Ⅲ度羊水胎粪污染应立即结束分娩。绒毛膜羊膜炎出现Ⅲ度羊水胎粪污染及Ⅲ度羊水胎粪污染伴随新生儿窒息可导致严重的围生期脑损伤。
Objective To investigate the relationship between third degree amniotic fluid meconium staining and neonatal brain tissue oxygen saturation and the impact of perinatal neonatal brain tissue oxygen saturation. Methods From January 2004 to March 2005, third-degree amniotic fluid meconium-stained full-term newborns delivered in the Department of Obstetrics and Gynecology, Second Clinical College of Jinan University from January 2004 to March 2005 were divided into three groups according to diagnostic criteria of meconium aspiration syndrome (MAS) And without MAS group, amniotic fluid of full-term newborn as a control group, neonatal 2 ~ 8h after birth, 2, 3, 5, 7 days to measure brain tissue oxygen saturation. Results The oxygen saturation of brain tissue of neonatal rats in MAS group was significantly lower than that of control group and non-MAS group on the 2nd, 8th, and 8th day after birth (P <0.01) The oxygen saturation of brain tissue in neonates at the 2nd and 3rd day was significantly lower than that in the control group, the difference was significant (P <0.01). The oxygen saturation of brain tissue in newborns of 2 ~ 8h after birth was significantly lower than that of cesarean section (P <0.01), and there was no significant difference on the 2nd, 3rd, 5th and 7th days (P> 0.05). Perinatal factors of persistent abnormalities in brain tissue oxygen saturation after birth are: chorioamnionitis with third degree amniotic fluid meconium staining and third degree amniotic fluid meconium staining with neonatal asphyxia. Conclusion Neonatal brain tissue oxygen saturation in MAS group is affected and brain injury occurs. Ⅲ degree amniotic fluid meconium should immediately end childbirth. Chorioamnionitis III degree of amniotic fluid meconium staining and amniotic fluid meconium Ⅲ degree with neonatal asphyxia can lead to severe perinatal brain injury.