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帕金森病(Parkinson’s disease,PD)是仅次于阿尔茨海默病的第二大神经退行性疾病,目前认为其是一种累及多系统的复杂性神经系统疾病。是一种进行性的锥体外系功能障碍的中枢神经系统退行性疾病,好发于中老年人群。典型临床症状是静止震颤、肌僵直、运动迟缓和姿势反射受损。PD的病因和发病机制极为复杂,迄今尚未完全阐明,治疗以对症治疗为主,目前仍无根治方法。PD的病因遗传因素:目前考虑与三种基因(Parkin基因、α-Synuclein基因、DJ-1基因)相关;年龄及性别因素:
Parkinson’s disease (PD) is the second largest neurodegenerative disease after Alzheimer’s disease and is now considered as a complicated multi-system neurological disease. Is a progressive extrapyramidal central nervous system degenerative disease that occurs in the elderly population. The typical clinical symptoms are quiescence tremor, stiffness, movement retardation, and impaired posture reflexes. The etiology and pathogenesis of PD is extremely complex, so far not yet fully understood, the treatment of symptomatic treatment based, there is still no cure. Etiological factors of PD: At present, consider the three genes (Parkin gene, α-Synuclein gene, DJ-1 gene); age and gender factors: